RESUMO
A novel HLA-B*07:461 and an extended HLA-C*15:193 allele were detected during routine HLA typing process.
Assuntos
Antígeno HLA-B7 , Antígenos HLA-C , Alelos , Sequência de Bases , Antígenos HLA-B/genética , Antígenos HLA-C/genética , Sequenciamento de Nucleotídeos em Larga Escala , HumanosRESUMO
The novel allele HLA-C*04:01:01:129 as compared to HLA-C*04:01:01:01 displays polymorphism at two positions; gDNA 2905 (C â T) and 2910 (T â A).
Assuntos
Genes MHC Classe I , Antígenos HLA-C , Alelos , Antígenos HLA-C/genética , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Índia , Polimorfismo GenéticoRESUMO
The novel allele HLA-DPB1*02:01:61 as compared with HLA-DPB1*02:01:02 displays polymorphism by a single nucleotide at gDNA 9011 C->T.
Assuntos
Povo Asiático , Alelos , Povo Asiático/genética , Sequência de Bases , Cadeias beta de HLA-DP/genética , HumanosRESUMO
The novel HLA-B*13:02:01:18 allele differs from HLA-B*13:02:01:01 by A->G nucleotide change at gDNA 2477.
Assuntos
Antígenos HLA-B , Sequenciamento de Nucleotídeos em Larga Escala , Alelos , Genes MHC Classe I , Antígenos HLA-B/genética , Humanos , NucleotídeosRESUMO
The novel HLA-B*51:01:01:83 allele differs from HLA-B*51:01:01:01 by A- > G nucleotide substitution at gDNA 2569.
Assuntos
Antígenos HLA-B , Sequenciamento de Nucleotídeos em Larga Escala , Alelos , Antígenos HLA-B/genética , Humanos , Índia , NucleotídeosRESUMO
The novel HLA-B*52:01:01:18 allele differs from HLA-B*52:01:01:02 by AâC nucleotide change at gDNA -155.
Assuntos
Antígenos HLA-B , Sequenciamento de Nucleotídeos em Larga Escala , Alelos , Genes MHC Classe I , Antígenos HLA-B/genética , Antígeno HLA-B52 , HumanosRESUMO
The novel HLA-B*35:03:01:22 allele differs from HLA-B*35:03:01:01 by a nucleotide change at gDNA 125 C â T.
Assuntos
Genes MHC Classe I , Sequenciamento de Nucleotídeos em Larga Escala , Alelos , Antígenos HLA-B/genética , Humanos , NucleotídeosRESUMO
The novel HLA-C*14:02:01:22 allele differs from HLA-C*14:02:01:01 by a nucleotide change at gDNA -156 C â T.
Assuntos
Antígenos HLA-C , Sequenciamento de Nucleotídeos em Larga Escala , Alelos , Genes MHC Classe I , Antígenos HLA-C/genética , HumanosRESUMO
The novel HLA-A*24:537 allele differs from HLA-A*24:02:01:01 by a nucleotide change at gDNA 294 C â T.
Assuntos
Sequenciamento de Nucleotídeos em Larga Escala , Nucleotídeos , Alelos , Antígenos HLA-A/genética , Humanos , Análise de Sequência de DNARESUMO
The novel HLA-C*04:01:01:102 allele differs from HLA-C*04:01:01:01 by G â A nucleotide change at gDNA 2591.
Assuntos
Antígenos HLA-C , Sequenciamento de Nucleotídeos em Larga Escala , Alelos , Genes MHC Classe I , Antígenos HLA-C/genética , Humanos , Análise de Sequência de DNARESUMO
Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. While spraying in the field, farmworkers get exposed to pesticides through the dermal route. Internalized pesticide inhibits AChE, which leads to neurotoxicity, cardiotoxicity, cognitive dysfunction, loss of endurance, and death in severe cases. Here, we present a nucleophilic pyridine-2-aldoxime-functionalized chitosan-based topical gel (poly-Oxime gel) that rapidly deactivates organophosphates, methyl parathion (MPT), on the skin of rats, which leads to reduced AChE inhibition in the blood and tissues. Testing the robustness of poly-Oxime gel, we report reduction in AChE inhibition following repeated dermal administration of MPT in the presence of poly-Oxime gel. Furthermore, poly-Oxime gel prevented MPT-induced neuromuscular dysfunction, loss of endurance, and locomotor coordination. We observe a 100% survival in rats following topical MPT administration in the presence of poly-Oxime gel. This prophylactic gel may therefore help farmworkers by limiting pesticide-induced toxicity and mortality.
